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dc.contributor.authorGüven, Melek Naz
dc.contributor.authorAltuncu, Merve S.
dc.contributor.authorBal, Tuğba
dc.contributor.authorOran, Dilem C.
dc.contributor.authorGülyüz, Ümit
dc.contributor.authorKızılel, Seda
dc.contributor.authorAvcı, Duygu
dc.date.accessioned2021-12-12T17:03:27Z
dc.date.available2021-12-12T17:03:27Z
dc.date.issued2018
dc.identifier.issn2470-1343
dc.identifier.urihttps://doi.org/10.1021/acsomega.8b01103
dc.identifier.urihttps://hdl.handle.net/20.500.11857/3681
dc.description.abstractTwo bisphosphonic acid-functionalized cross-linkers (one novel) with different spacer chain characteristics were synthesized and incorporated into hydrogels by copolymerization with 2-hydroxyethyl methacrylate at different ratios to control the hydrogels' swelling, mechanical properties, and ability to support mineralization for biomedical applications. The cross-linkers were synthesized by reaction of 2-isocyanatoethyl methacrylate and bisphosphonated diamines followed by selective dealkylation of the bisphosphonate ester groups. The hydrogels provide in vitro growth of carbonated apatite, morphology affected by the cross-linker structure. The hydrogels exhibit a high Young's modulus E (up to 400 kPa) and can sustain up to 10.2 +/- 0.1 MPa compressive stresses. E and hence the cross-link density significantly increases upon mineralization reflecting the formation of many bisphosphonate BP-Ca2+ bonds acting as additional cross-links. Cyclic mechanical tests reveal self-recoverability of hydrogels because of reversible nature of BP-Ca2+ bonds. The results suggest that these cross-linkers can add calcium-binding abilities to hydrogels synthesized from any monomer and improve their mechanical, swelling, and mineralization properties and hence are potentially useful materials for biomedical applications.en_US
dc.description.sponsorshipBogazici University Research FundBogazici University [11820]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciencesen_US
dc.description.sponsorshipThe authors would like to acknowledge the financial support from Bogazici University Research Fund (11820). O.O. thanks the Turkish Academy of Sciences (TUBA) for the partial support.en_US
dc.language.isoengen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Omegaen_US
dc.identifier.doi10.1021/acsomega.8b01103
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone Tissueen_US
dc.subjectIn-Vitroen_US
dc.subjectBiomimetic Mineralizationen_US
dc.subjectNetwork Hydrogelsen_US
dc.subjectPhosphateen_US
dc.subjectBiomineralizationen_US
dc.subjectCalcificationen_US
dc.subjectPolymersen_US
dc.subjectDifferentiationen_US
dc.subjectNanocompositesen_US
dc.titleBisphosphonic Acid-Functionalized Cross-Linkers to Tailor Hydrogel Properties for Biomedical Applicationsen_US
dc.typearticle
dc.authoridOkay, Oguz/0000-0003-2717-4150
dc.authoridKizilel, Seda/0000-0001-9092-2698
dc.authoridAvci, Duygu/0000-0002-9927-0291
dc.authoridGULYUZ, Umit/0000-0001-7507-0909
dc.authoridBal, Tugba/0000-0003-2100-285X
dc.departmentMeslek Yüksekokulları, Lüleburgaz Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü
dc.identifier.volume3en_US
dc.identifier.startpage8638en_US
dc.identifier.issue8en_US
dc.identifier.endpage8647en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57190073458
dc.authorscopusid57203228296
dc.authorscopusid56370551600
dc.authorscopusid57201354151
dc.authorscopusid55893853400
dc.authorscopusid9734896800
dc.authorscopusid7005349580
dc.identifier.wosWOS:000440617900022en_US
dc.identifier.scopus2-s2.0-85050974067en_US
dc.identifier.pmidPubMed: 31458994en_US
dc.authorwosidAvci, Duygu/AAN-3288-2020
dc.authorwosidOkay, Oguz/G-3794-2011
dc.authorwosidKizilel, Seda/P-3959-2014
dc.authorwosidBal, Tugba/ABE-5050-2021


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